323_RufoNovel

DataONE2022-09-22 更新2024-06-08 收录

抗结核药物发现

天然产物结构

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资源简介：

Raw data associated with the publication on \"New Rufomycins from Streptomyces atratus MJM3502 Expand Anti-Mycobacterium tuberculosis Structure−Activity Relationships\" in Organic Letters

创建时间：

2023-11-14

Virtual Screening and X‑ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

抗结核药物发现

X射线晶体学药物设计

Thymidylate synthase X (ThyX) represents an attractive target for tuberculosis drug discovery. Herein, we selected 16 compounds through a virtual screening approach. We solved the first X-ray crystal

NIAID Data Ecosystem50

Co-cultivation induces elicitation of unique Fungus-derived Natural products that leads to thiol stress mediated killing of Mycobacterium tuberculosis [Fun31]

抗结核药物发现

真菌共培养

Tuberculosis, caused by Mycobacterium tuberculosis has remained a leading cause of death worldwide even after decades of it being declared as global health emergency by the WHO. Newer drugs with novel

NIAID Data Ecosystem20

Looking Back to the Future: Predicting in Vivo Efficacy of Small Molecules versus Mycobacterium tuberculosis

抗结核药物发现

机器学习药物筛选

Selecting and translating in vitro leads for a disease into molecules with in vivo activity in an animal model of the disease is a challenge that takes considerable time and money. As an example, rece

NIAID Data Ecosystem20

Solution NMR Structure of the lasso peptide chlorolassin

核磁共振结构解析

天然产物结构

Solution NMR Structure of the lasso peptide chlorolassin

NIAID Data Ecosystem30

Analogues of the Herbicide, N ‑Hydroxy‑ N ‑isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads

抗结核药物发现

抑制剂优化

New drugs to treat tuberculosis (TB) are urgently needed to combat the increase in resistance observed among the current first-line and second-line treatments. Here, we propose ketol-acid reductoisome

NIAID Data Ecosystem20

323_RufoNovel

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