The crystal structure of acyltransferase in complex with octanoyl-CoA and teicoplanin

The crystal structure of acyltransferase in complex with octanoyl-CoA and teicoplanin Descriptor: 2-amino-2-deoxy-beta-D-glucopyranose, OCTANOYL-COENZYME A, Putative uncharacterized protein tcp24, ... Authors: Li, T.-L, Lyu, S.-Y, Liu, Y.-C, Chang, C.-Y, Huang, C.-J. Deposit date: 2014-04-11 Release date: 2014-09-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus J.Am.Chem.Soc., 136, 2014

与辛酰基辅酶A（octanoyl-CoA）及替考拉宁（teicoplanin）结合的酰基转移酶（acyltransferase）晶体结构；描述项：2-氨基-2-脱氧-β-D-吡喃葡萄糖（2-amino-2-deoxy-beta-D-glucopyranose）、辛酰基辅酶A（OCTANOYL-COENZYME A）、推定未表征蛋白tcp24（Putative uncharacterized protein tcp24）等；作者：Li, T.-L、Lyu, S.-Y、Liu, Y.-C、Chang, C.-Y、Huang, C.-J；入库日期：2014-04-11；发布日期：2014-09-10；最后修改日期：2023-11-08；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.35埃（Å）；引用文献：长链脂肪族N-酰基转移酶的多种复合物可合成2,6-二酰化/2-酰基取代糖肽类抗生素，可有效杀灭耐万古霉素肠球菌，《美国化学会志》（J.Am.Chem.Soc.），第136卷，2014年