Laminar shear stress inhibits endothelial-mesenchymal transition and improves atherosclerosis through SRXN1

Atherosclerosis (AS) is one of the main causes of cardiovascular diseases, and its complex pathophysiological mechanism involves the interaction of multiple factors. Laminar shear stress (LSS) plays a key role in the regulation of AS processes, but its specific mechanism is still unclear. In this study, we analyzed the proteome data of static culture and LSS-treated human aortic endothelial cells (HAECs), to explore the role and potential mechanism of LSS in AS.