GWAS summary statistics for statin-associated muscle phenotypes in the UK Biobank and All of Us Research Program

GWAS summary statistics accompanying Kim et al., "Genetic Associations of Creatine Kinase–Anchored Statin-Associated Muscle Phenotypes in the UK Biobank and All of Us" (submitted to the Journal of the American Heart Association). This deposit contains per-cohort, single-variant association summary statistics from the UK Biobank (UKB) and the All of Us Research Program (AoU) for statin-associated muscle phenotypes anchored on serum creatine kinase (CK) elevations and statin treatment modification. Cohorts and genome builds UK Biobank: GRCh37/hg19, variants identified by rsID All of Us: GRCh38/hg38, variants identified by chr:pos:ref:alt Each cohort was analyzed on its native build; coordinates were not lifted in the deposited per-cohort files. Phenotypes CK severity tiers anchored on sex-specific upper limits of normal (ULN; 180 IU/L for men, 120 IU/L for women): GSI (general statin intolerance): CK > 1×ULN SRM (statin-related myopathy): CK > 4×ULN SRSR (statin-related suspected rhabdomyolysis): CK > 10×ULN For each severity tier, the deposit includes (i) a primary treatment-modification phenotype (qualifying CK elevation plus ≥3 statin switches or ≥9 months statin discontinuation, restricted to individuals with ≥2 statin prescriptions); (ii) a complementary CK-only phenotype (biomarker-defined muscle injury without the treatment-modification requirement); and, for SRM and SRSR, (iii) a mutually exclusive severe-tier subgroup (SRM_excl, SRSR_excl). Data format Tab-separated, gzip-compressed files following the GWAS-SSF column convention: chromosome, base_pair_location, effect_allele, other_allele, beta, standard_error, effect_allele_frequency, p_value, variant_id. All 16 files share an identical 9-column schema. See README.md in this dataset for column descriptions. Statistical model Single-variant association tested with SAIGE (binary trait), adjusted for age, sex, and 10 genetic principal components, in European-ancestry participants. Full phenotype definitions, sample sizes, and meta-analysis results are reported in the manuscript (Methods, Table 2, and Supplementary Tables 1–2).