Integrated quantitative sensory testing and psychological phenotyping dataset for capsaicin-induced neuropathic pain susceptibility

This dataset contains quantitative sensory testing (QST) data and psychological questionnaire scores from 110 healthy adults who underwent standardized sensory testing under two conditions: on untreated (control) skin and on skin that was sensitized with topical capsaicin. The study examined whether neuropathic pain-like patterns could be induced experimentally and whether individuals susceptible to this condition could be identified based on psychological traits. A key finding was that, after capsaicin sensitization, 18% of participants showed QST profiles resembling clinical neuropathic pain in 50-60% of parameters; these individuals also exhibited a more pessimistic life orientation, as measured by the Life Orientation Test. File overview: File 1: qst_z_scores.csv: This file contains z-transformed QST data (110 × 23). The first column ("ID") lists subject identifiers that are consistent across files. The remaining 22 columns provide z-scores for 11 QST parameters at the control site (z_contr) and the capsaicin-treated site (z_test). Z-scores are based on an age-, sex-, and site-matched reference cohort. Z-scores greater than 0 indicate increased sensitivity and z-scores less than 0 indicate decreased sensitivity. Parameters: CDT, cold detection threshold; CPT, cold pain threshold; HPT, heat pain threshold; MDT, mechanical detection threshold; MPS, mechanical pain sensitivity; MPT, mechanical pain threshold; PPT, pressure pain threshold; TSL, thermal sensory limen; VDT, vibration detection threshold; WDT, warm detection threshold; WUR, wind-up ratio. Raw values can be reconstructed using reference means and standard deviations. This file partially overlaps with a related dataset published at Mendeley Data: "Quantitative sensory testing and classical pain model dataset in 127 healthy volunteers" (DOI:10.17632/9v8ndhctvz.2). Here, z-transformed QST values are provided for both the capsaicin-treated test site and the untreated contralateral control site. The previously published dataset only contains control site raw values. File 2: psy_questionnaire_scores.csv: This file contains 110 questionnaire scores with consistent subject IDs. Seven measures are included: PCS, Pain Catastrophizing Scale; PASS, Pain Anxiety Symptoms Scale; PVAQ, Pain Vigilance and Awareness Questionnaire; ADS, “Allgemeine Depressionsskala” (depression); STAI, State-Trait Anxiety Inventory; LOT, Life Orientation Test (optimism); SOMS, Screening for Somatoform Disorders. File 3: participant_metadata.csv: The metadata file contains 110 rows and six columns. IDs match those in other files. The variables include age (years), sex (1 = male, 0 = female), test site code, control site code (1 = hand, 2 = foot, 3 = forearm, 4 = face, 5 = back/shoulder/neck, 6 = back/pelvis, 7 = thigh), and neuropathic pattern (1 = present, 0 = absent). The IDs are arbitrary, and the dataset is fully anonymized.本数据集包含110名健康成年人的定量感觉测试（quantitative sensory testing, QST）数据与心理问卷得分。所有受试者在两种皮肤条件下接受了标准化感觉测试：未处理（对照）皮肤，以及经外用辣椒素致敏的皮肤。本研究旨在探究是否可通过实验手段诱发神经病理性疼痛样特征，以及能否基于心理特质识别该易感人群。核心研究结果显示：经辣椒素致敏后，18%的受试者在50%~60%的参数上呈现出与临床神经病理性疼痛相似的QST特征；此类受试者同时表现出更消极的生活取向，该结果通过生活取向测试（Life Orientation Test）测得。 ### 文件概览 1. **qst_z_scores.csv** 该文件包含经z变换的QST数据（维度为110×23）。第一列（"ID"）为受试者标识符，在所有文件中保持一致。其余22列分别为对照位点（z_contr）与辣椒素处理位点（z_test）的11项QST参数的z分数。z分数基于年龄、性别、位点匹配的参照队列计算得到：z分数大于0表示敏感性升高，小于0表示敏感性降低。本次涵盖的参数包括：冷检测阈值（cold detection threshold, CDT）、冷痛阈值（cold pain threshold, CPT）、热痛阈值（heat pain threshold, HPT）、机械检测阈值（mechanical detection threshold, MDT）、机械痛敏感性（mechanical pain sensitivity, MPS）、机械痛阈值（mechanical pain threshold, MPT）、压力痛阈值（pressure pain threshold, PPT）、温度感觉阈（thermal sensory limen, TSL）、振动检测阈值（vibration detection threshold, VDT）、温检测阈值（warm detection threshold, WDT）以及风增敏比值（wind-up ratio, WUR）。原始数值可通过参照队列的均值与标准差进行重建。 本文件与Mendeley Data平台发布的相关数据集存在部分重叠：该数据集题为《127名健康志愿者的定量感觉测试与经典疼痛模型数据集》（DOI:10.17632/9v8ndhctvz.2），仅提供对照位点的原始数值；而本文件同时提供了辣椒素处理测试位点与未处理对侧对照位点的z变换QST值。 2. **psy_questionnaire_scores.csv** 该文件包含110份问卷得分，受试者ID与其他文件保持一致。共涵盖7项测评指标：疼痛灾难化量表（Pain Catastrophizing Scale, PCS）、疼痛焦虑症状量表（Pain Anxiety Symptoms Scale, PASS）、疼痛警觉与意识问卷（Pain Vigilance and Awareness Questionnaire, PVAQ）、德国抑郁自评量表（"Allgemeine Depressionsskala", ADS）、状态-特质焦虑量表（State-Trait Anxiety Inventory, STAI）、生活取向测试（Life Orientation Test, LOT，用于评估乐观倾向）、躯体形式障碍筛查量表（Screening for Somatoform Disorders, SOMS）。 3. **participant_metadata.csv** 该元数据文件包含110行数据与6列变量，受试者ID与其他文件完全匹配。变量包括：年龄（单位：岁）、性别（1=男性，0=女性）、测试位点编码、对照位点编码（1=手，2=足，3=前臂，4=面部，5=背部/肩部/颈部，6=背部/骨盆，7=大腿）以及神经病理性疼痛模式（1=存在，0=不存在）。受试者ID为随机设定，本数据集完全匿名。