A systematic assessment of medical diagnoses preceding the first diagnosis of multiple sclerosis: Supplementary materials

Objective: To explore the occurrence of diseases and symptoms in the five years prior to diagnosis in patients with multiple sclerosis (MS) in a case-control study. Methods: Using ambulatory claims data we systematically assessed differences in the occurrence of diseases and symptoms in the five years prior to first diagnosis in patients with MS (n=10,262) as compared to patients with two other autoimmune diseases – Crohn’s disease (n=15,502) and psoriasis (n=98,432) - and individuals without these diseases (n=73,430). Results: Forty-three ICD-10 codes were recorded more frequently for patients with MS before diagnosis as compared to controls without autoimmune disease. Many of these findings were confirmed in a comparison to the other control groups. A high proportion of these ICD-10 codes represent symptoms suggestive of demyelinating events or other neurological diagnoses. In a sensitivity analysis excluding patients with such recordings prior to first diagnosis, no association...研究目的：本病例对照研究旨在探讨多发性硬化（multiple sclerosis, MS）患者确诊前5年内的疾病与症状发生情况。 研究方法：本研究采用门诊诊疗索赔数据，系统评估了多发性硬化患者（n=10,262）首次确诊前5年内的疾病与症状发生频次，并对比其与另外两种自身免疫性疾病患者——克罗恩病（Crohn’s disease）患者（n=15,502）、银屑病（psoriasis）患者（n=98,432），以及无上述疾病的对照个体（n=73,430）之间的发生差异。 研究结果：相较于无自身免疫性疾病的对照组，多发性硬化患者确诊前的43项ICD-10（International Classification of Diseases 10th Revision）编码记录频次更高。其中多数研究结果在与其他对照组的对比中得到验证。此类ICD-10编码中，有较高比例对应提示脱髓鞘事件或其他神经系统疾病的症状。在一项排除首次确诊前存在此类记录的患者的敏感性分析中，未发现显著关联……