Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Polycomb group proteins play important roles in developmental and cell proliferation processes. We demonstrate that the PRC1 protein CBX2 is critical for heterochromatin homeostasis, chromosome stability and the prevention of premature cellular senescence. Purpose: Use of Next-generation sequencing (NGS) to assess transcriptional (RNAseq) profiles and changes in chromatin accessibility in WT and Cbx2-/- fibroblasts prior to the onset of premature senescence.
提供机构：
University of Georgia
创建时间：
2022-02-20
