Plasma BDNF and LF independently associated with reverse-dipper pattern of nocturnal blood pressure change.

Multiple logistic regression analyses were performed. The covariates included age, male sex, classical cardiovascular risk factors (body mass index, current smoking, cardiovascular disease history, dyslipidemia, diabetes mellitus, eGFR), medical hypertension treatment (calcium-channel blocker, α or β blocker, ACE inhibitor or ARB, diuretic agent) and AHI. Each model includes a HRV parameter with or without BDNF in addition to the above covariates. Model 1: + ln(BDNF), Model 2: + ln(SDNN), Model 3: + ln(SDNN) and ln(BDNF), Model 4: + ln(SDANN5), Model 5: + ln(SDANN5) and ln(BDNF), Model 6: + ln(CVRR), Model 7: +ln(CVRR) and ln(BDNF), Model 8: +ln(LF), and Model 9: + ln(LF) and ln(BDNF). The HRV parameters and BDNF were natural logarithm-transformed (ln) to achieve a normal distribution. OR; odds ratio, CI; confidence interval, eGFR; estimated glomerular filtration rate, ACE; angiotensin converting enzyme, ARB; angiotensin receptor blocker, AHI; apnea hypopnea index, SDNN; standard deviation of NN(RR) interval, SDANN5; standard deviation of average of NN intervals for each 5 minute period, CVRR; coefficient of variation R-R interval, LF; low frequency power, BDNF; brain-derived neurotrophic factor.