A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

A new population of dysfunctional astrocytes in the aging mouse hippocampus called autophagy-dysregulated astrocytes (APDAs) show impaired protein homeostasis and defective regulation of synapse formation and elimination and appear early in a mouse model of Alzheimer's disease. Single cell RNA-seq of 2-year-old WT mouse brains, Six hippocampi were analyzed在衰老小鼠海马体中存在一类功能异常的星形胶质细胞（astrocytes）新类群，被命名为自噬失调星形胶质细胞（autophagy-dysregulated astrocytes, APDAs）。该类群细胞存在蛋白质稳态受损、突触形成与消除的调控缺陷，且在阿尔茨海默病（Alzheimer's disease）小鼠模型中早期出现。本数据集通过对2岁龄野生型（WT）小鼠脑组织开展单细胞RNA测序（single cell RNA-seq），共分析了6个海马体样本。