DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha repressor

Dual-specificity phosphatase 8 is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. To investigate T-cell profiles and potential immune phenotypes of T-DUSP8 cKO mice, unstimulated T cells from the spleen and lymph nodes of 6-month-old mice were subjected to single cell-RNA sequencing (scRNA-seq) analysis.