Rh(I)-Catalyzed Asymmetric Synthesis of 3-Substituted Isoindolinones through CO Gas-Free Aminocarbonylation
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https://figshare.com/articles/dataset/Rh_I_Catalyzed_Asymmetric_Synthesis_of_3_Substituted_Isoindolinones_through_CO_Gas_Free_Aminocarbonylation/2539672
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资源简介：
A highly efficient and accessible synthesis of chiral
3-substituted
isoindolinone frameworks is described. The synthesis involved the
Rh(I)-catalyzed asymmetric arylation of boronic acids to 2-halobenzaldimines
and the subsequent Rh(I)-catalyzed intramolecular aminocarbonylation
of the resulting 2-halobenzylamines using an aldehyde as the carbonyl
source. The method tolerates a variety of functional groups, yielding
isoindolinone derivatives in moderate to high yields with high ee-values.
In addition, two Rh(I)-catalyzed transformations could be efficiently
accomplished in a one-pot sequence to give chiral isoindolinones by
the simple addition of a ligand and an aldehyde after the Rh(I)-catalyzed
asymmetric arylation.
创建时间：
2016-02-21
