Plasma protein profiling in patients with neutropenia

Quantification of 249 plasma proteins in 53 adult neutropenia patients and 20 age- and sex-matched controls, as well as 10 children with neutropenia and 5 child controls. The log2-transformed Normalized Protein eXpression (NPX) unit is used for all values. For this reason, values from different proteins cannot be compared. Proteins with more than 50% missing values were excluded from the analysis. Missing values for 12 of the remaining 249 proteins were replaced with Limit of Detection (LOD) values. Missing values in the published data set are caused by samples being excluded from some of the panels due to technical issues. Please refer to the referenced published article for technical details, clinical information and interpretation: Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia (Sohlberg et al., Blood, 2021).本数据集针对53名成人中性粒细胞减少症患者及20名年龄、性别匹配的健康对照个体，同时纳入10名儿童中性粒细胞减少症患者与5名儿童健康对照，对其中249种血浆蛋白完成定量检测。所有数值均采用经log₂转换的归一化蛋白表达（Normalized Protein eXpression, NPX）单位。因此，不同蛋白的检测结果无法进行跨蛋白比较。缺失值占比超过50%的蛋白被排除于本次分析之外；剩余249种蛋白中，有12种的缺失值采用检测限（Limit of Detection, LOD）值进行填补。本公开数据集内的缺失值源于部分样本因技术故障被排除在部分检测组块之外。相关技术细节、临床信息及结果解读请参阅已发表论文：《慢性中性粒细胞减少症中与疾病严重程度相关的自然杀伤细胞稳态失衡》（Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia, Sohlberg et al., Blood, 2021）。