Data from: Keeping pace with the Red Queen: identifying the genetic basis of susceptibility to infectious disease

Genome-wide association studies are widely used to identify "disease
genes" conferring resistance/susceptibility to infectious diseases.
Using a combination of mathematical models and simulations we demonstrate
that genetic interactions between hosts and parasites (GxG interactions)
can drastically affect the results of these association scans and hamper
our ability to detect genetic variation in susceptibility. When hosts and
parasites coevolve, these GxG interactions often make Genome-wide
association studies unrepeatable over time or across host populations.
Reanalyzing previously published data on Daphnia magna susceptibility to
infection by Pastueria ramosa, we identify genomic regions consistent with
GxG interactions. We conclude by outlining possible avenues for designing
more powerful and more repeatable association studies.