Assessment of pulmonary remodeling and heart weight.

An increased lung weight-to-tibia length (LuW/TL) ratio [mg/mm] indicated the presence of pulmonary remodeling in the mice with a severe constriction (†, P<0.01), but not in the mice with a mild constriction. No differences between groups were observed in the lung water content, indicated by a constant lung wet weight-to-dry weight ratio (ww/dw) (P>0.05). Post mortem whole heart weight-to-tibia length ratio was significantly increased in severe TAC mice (P<0.001), but the increase in the mild TAC mice did not reached statistical significance (P>0.05).