Nomenclature for CNV dynamics.

We classify CNV progression dynamics in each simulation based on its early and lateCNV types, allowing for nine CNV-dynamics scenarios. We use the term progression when a simulation replica initially develops either Early Type 1 CNV or Early Type 2 CNV and then develops Late Type 3 CNV and translocation when a replica initially develops either Early Type 1 CNV or Early Type 3 CNV, then Late Type 2 CNV or initially develops either Early Type 2 CNV or Early Type 3 CNV, then Late Type 1 CNV. Three translocation scenarios, T21, T31 and T32, did not occur in our simulations.