Andersen2009 - Genome-scale metabolic network of Aspergillus niger (iMA871)

Andersen2009 - Genome-scale metabolic network
of Aspergillus niger (iMA871)

This model is described in the article:

Metabolic model integration
of the bibliome, genome, metabolome and reactome of Aspergillus
niger.

Andersen MR, Nielsen ML, Nielsen
J.
Mol. Syst. Biol. 2008; 4: 178
Abstract:

The release of the genome sequences of two strains of
Aspergillus niger has allowed systems-level investigations of
this important microbial cell factory. To this end, tools for
doing data integration of multi-ome data are necessary, and
especially interesting in the context of metabolism. On the
basis of an A. niger bibliome survey, we present the largest
model reconstruction of a metabolic network reported for a
fungal species. The reconstructed gapless metabolic network is
based on the reportings of 371 articles and comprises 1190
biochemically unique reactions and 871 ORFs. Inclusion of
isoenzymes increases the total number of reactions to 2240. A
graphical map of the metabolic network is presented. All levels
of the reconstruction process were based on manual curation.
From the reconstructed metabolic network, a mathematical model
was constructed and validated with data on yields, fluxes and
transcription. The presented metabolic network and map are
useful tools for examining systemwide data in a metabolic
context. Results from the validated model show a great
potential for expanding the use of A. niger as a high-yield
production platform.

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