Human jak1 kinase domain in complex with inhibitor

Human jak1 kinase domain in complex with inhibitor Descriptor: Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide Authors: Read, J.A, Augustin, M, Lammens, A. Deposit date: 2018-05-03 Release date: 2019-05-22 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling To Be Published与抑制剂结合的人JAK1激酶结构域 描述：酪氨酸蛋白激酶JAK1（Tyrosine-protein kinase JAK1），N-[5-甲基-4-[7-[[(2R)-2-(4-甲基哌嗪-1-基)丙酰基]氨基]-1H-吲哚-3-基]嘧啶-2-基]环丙烷甲酰胺 作者：Read, J.A、Augustin, M、Lammens, A. 提交日期：2018-05-03 发布日期：2019-05-22 最后修改日期：2024-10-23 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å 引用：一种强效选择性JAK1抑制剂对肺部局部炎症的抑制作用；JAK1而非JAK3的激活对IL-4R介导的免疫细胞信号传导至关重要，待发表