Compound 7, containing a triazolopyridine, is a selective PIM-1 inhibitor.

IC50 values were obtained as described in the Methods Section.
aThe values reported are an average of two independent data points; those related to compound 1 have been previously reported.21
bThis designation indicates that the improvement in percentage of inhibition was equal or greater than 25%.
cThis designation indicates that the improvement in percentage of inhibition was equal or greater than 50%. Inhibitors were used at a final concentration of 10 µM. Details of the assay conditions can be found at www.ProQinase.com.