Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

Despite the recent scientific advancements, pancreatic cancer remains the 7th leading cause of cancer-related mortality. Pancreatic cancer progression is closely associated with inflammation, and we previously showed that short hairpin RNA–mediated knockdown of sST2 expression, a soluble decoy receptor for the proinflammatory molecule interleukin-33 (IL-33), in mouse Panc02 pancreatic cancer cells reduced malignant growth following pancreatic (orthotopic) implantation. Furthermore, this growth suppression was accompanied by decreased tumor angiogenesis, reduced expression of the neutrophil chemoattractant CXCL3, and a lower number of tumor-associated neutrophils (TANs). In contrast to previous results, in this study, we showed that IL-33-dependent tumor growth and pulmonary metastasis occurred following subcutaneous (ectopic) implantation of sST2-knockdown cells. This was associated with a decrease in the levels of the anti-inflammatory molecule adiponectin and the number of GLUT4-posit..., Differentially expressed chemokine and cytokine genes in Panc02-shCont and Panc02-sh#5 tumors were analyzed using a Mouse Cytokines & Chemokines RT2 Profiler PCR Array (QIAGEN #PAMM-150Z)., , # Data from: Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

[https://doi.org/10.5061/dryad.g1jwstr2n](https://doi.org/10.5061/dryad.g1jwstr2n)

This dataset corresponds to Fig. S4 of the manuscript titled *\"Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells.\"* Fig. S4 presents the cytokine and chemokine gene expression profiles obtained using a PCR array in Panc02 tumors with or without sST2 knockdown. The submitted files include:

**Gene_table.csv**: Primer positions and gene information used in the PCR array, including Unigene and RefSeq IDs, gene symbols, descriptions, and official gene names.

**Ct_table.csv**: Raw cycle threshold (Ct) values detected for each gene in control (shCont) and sST2-knockdown (sh#5) Panc02 tumors.

**Delta_Ct_table.csv**: Normalized Ct values using *Gapdh* as the internal control, and ΔΔCt value...,