Identified bow-tie network and its schematic diagram.

(A)The bow-tie structure identified from the protein functional networks. The pointed arrows represent the activation action by source onto the target gene and the flattened end arrows suggest inhibitory action. (B) Schematic representation of the structure used for ODE modeling. Kd1d2, Ke1e2, Ka1a2, Kb1m, Kd2m, Ke2m, , Kf1m and Kc1m represents the upstream (input to the core of the bow-tie structure) rate constants of the signaling network. And Kmn, Ka2a3, Kna3, , Knb2, Knd3, , Kne3, Knf2 and represents the downstream rate constants of the network structure. Da1, Da2, Da3, Da4, Db1, Db2, Dc1, Dd1, Dd2, Dd3, De1, De2, De3, Df1, Df2, Dm, and Dn represent the decay rate constant of the activated components A1, A2, A3, A4, B1, B2, C1, D1, D2, D3, E1, E2, E3, F1, F2, M, and N respectively. The constants Ke2m, Knd3, Kna3, Knf2 represents the activation kinetic constants for basal production of the components M, D3, A3, and F2 respectively.