CYTH proteins bind ARF1:GTP

Cytohesin (CYTH) proteins 1, 2, 3 and 4 are ARF guanine nucleotide exchange factors (GEFs) for ARF1 as well as other ARFs. Recruitment to the membrane is mediated by direct interaction with ARF1:GTP as well as an interaction between the CYTH plexstrin homology (PH) domain and the lipid membrane (Chardin et al, 1996; Betz et al, 1998; Mossessova et al, 1998; Cherfils et al, 1998; Franco et al, 1998; Osagawara et al, 2000; Malaby et al, 2013).

细胞粘附素（Cytohesin，简称CYTH）蛋白1、2、3和4是ARF鸟苷酸交换因子（GEFs），作为ARF1的交换因子，亦作用于其他ARF。其膜招募过程通过直接与ARF1:GTP相互作用，以及细胞粘附素（CYTH）的plexstrin同源（PH）结构与脂质膜之间的相互作用来实现（Chardin et al, 1996；Betz et al, 1998；Mossessova et al, 1998；Cherfils et al, 1998；Franco et al, 1998；Osagawara et al, 2000；Malaby et al, 2013）。