Spodoptera frugiperda Raw sequence reads. Spodoptera frugiperda

N6-methyladenosine RNA (m6A) is the most abundant modification of messenger RNA (mRNA), which has been demonstrated in regulating various post-transcriptional processes and playing key roles in sex determination, neuronal functions, and embryonic development in Drosophila and mice. However, the methylation profile and relevant functions in other insects remain largely unknown. Here, we analyzed transcriptome-wide profile of m6A modification in the embryonic development of a destructive agricultural pest Spodoptera frugiperda. Our study showed that differentially expressed m6A peak-modified genes were enriched in cell and organ development between the 2 h and 24 embryos. Our study reveals that RNA m6A epigenetic regulation in the embryonic development of S. frugiperda, and provides new insight for the embryonic development of insects.