A systematic review on the implementation and reporting of refinements in mouse telemetry implantation surgery using electrocardiography (ECG) recording devices

In this systematic review, we will provide an overview of all reported procedures in mouse studies until 31.12.2019 using surgery that involves the placing of ECG recording telemetry devices and an overview of the methodological quality of all these studies. Furthermore, we will investigate and report the trends in refinements observed until 31.12.2019. Additionally, a comparison will be made between the periods before and after 2010 (when the ARRIVE Guidelines were developed, as a tool to evaluate reporting quality). Lastly, we will investigate the different factors affecting the welfare of the animals after the implantation surgery.

The ECG telemetry implantation surgery was chosen among other types of existing telemetric measurements because of its potential increased severity (especially when the device is implanted in the intraperitoneal region of the animal). This way we will achieve to showcase possible refinements that have been applied during the course of time in the field of biotelemetry, and more specifically when ECG recording devices are utilized.

In the attached files a detailed protocol can be found (based on the format by SYRCLE, version 2.0) and a file containing the search strategy (with the specific search strings used), that was performed on three databases (PubMed, World of Science and Embase) on 29.02.2020, as well as the number of items found on each database.

在本项系统评价中，我们将对截至2019年12月31日所有报道的涉及植入心电图记录遥测设备的外科手术方法进行综述，并对这些研究的方法论质量进行概述。此外，我们还将调查并报告截至2019年12月31日观察到的改进趋势。进一步地，我们将对比2010年前后（ARRIVE指南发布之时，该指南作为评估报告质量的一种工具）的时期差异。最后，我们将探究影响动物植入手术后福利的多种因素。由于心电图遥测植入手术相较于其他类型的现有遥测测量具有潜在的更高严重性（尤其是在设备植入动物腹腔区域时），因此我们选择进行此项手术。通过这种方式，我们将展示在生物遥测领域，特别是在心电图记录设备应用过程中，随着时间的推移所应用的可能的改进。在所附文件中，可以找到详细的方案（基于SYRCLE格式2.0版）以及包含特定搜索字符串的搜索策略文件，该文件于2020年2月29日在三个数据库（PubMed、World of Science和Embase）中进行搜索，以及每个数据库中找到的项目数量。