Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione

Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione Descriptor: 1,2-ETHANEDIOL, 8-[[(3R,4R)-3-[[1,1-bis(oxidanylidene)thian-4-yl]methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-one, ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2, ... Authors: Chung, C, Bamborough, P, Demont, E. Deposit date: 2015-07-11 Release date: 2015-08-12 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors. J.Med.Chem., 58, 2015

人类ATAD2溴结构域（bromodomain）与4-((3R,4R)-4-[3-甲基]-5-(5-甲基吡啶-3-基)-2-氧代-1,2-二氢喹啉-8-基)氨基哌啶-3-基氧基甲基)-1-硫杂环己烷-1,1-二氧化物复合物的晶体结构。描述符：1,2-乙二醇，8-[[(3R,4R)-3-[[1,1-二氧代硫杂环己-4-基]甲氧基]哌啶-4-基]氨基]-3-甲基-5-(5-甲基吡啶-3-基)-1H-喹啉-2-酮，ATP酶家族AAA结构域包含蛋白2（ATPase Family AAA Domain-Containing Protein 2）……作者：Chung, C, Bamborough, P, Demont, E. 存入日期：2015-07-11，发布日期：2015-08-12，最后修改日期：2024-05-08。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.09埃（Å）。引用文献：《基于结构的萘啶酮类化合物优化为强效Atad2溴结构域抑制剂》，《药物化学杂志》（J.Med.Chem.），58卷，2015年