Autophagy is an evolutionarily conserved catabolic process that directs cytoplasmic proteins, organelles and microbes to lysosomes for degradation. Autophagy acts at the intersection of pathways invol
The STING signaling pathway is essential for the innate immune response to DNA viruses and bacteria and is important in tumor immunity. STING binding to cGAMP or to synthetic agonists leads to the act
Activated effector T cells (Teff) and/or compromised regulatory T cells (Treg) underlie chronic inflammatory diseases. We discovered a novel pathway to inhibit survival and expansion of Teff without c
