Cryo-EM structure of human XPR1 with InsP8 in an 'arch-like' intermediate state of the SPX domain

Cryo-EM structure of human XPR1 with InsP8 in an 'arch-like' intermediate state of the SPX domain Descriptor: (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], Solute carrier family 53 member 1 Authors: Wang, X, Bai, Z, Wallis, C, Wang, H, Han, Y, Jin, R, Lei, M, Gu, C, Jessen, H, Shears, S, Sun, Y, Corry, B, Zhang, Y. Deposit date: 2024-10-11 Release date: 2025-08-27 Last modified: 2025-09-17 Method: ELECTRON MICROSCOPY (3.31 Å) Cite: KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1. Mol.Cell, 85, 2025

人源XPR1结合肌醇八磷酸（InsP8）处于SPX结构域"弓形"中间态的冷冻电镜结构
描述物：(1R,3S,4R,5S,6R)-2,4,5,6-四(膦酰氧基)环己烷-1,3-二基双[三氢(二磷酸酯)]，溶质载体家族53成员1（Solute carrier family 53 member 1）
作者：Wang X, Bai Z, Wallis C, Wang H, Han Y, Jin R, Lei M, Gu C, Jessen H, Shears S, Sun Y, Corry B, Zhang Y
提交日期：2024-10-11
发布日期：2025-08-27
最后修改日期：2025-09-17
检测方法：冷冻电子显微镜法（分辨率3.31 Å）
引用文献：《KIDINS220与InsP8保障磷酸盐输出蛋白XPR1的分步调控》，《分子细胞》（Molecular Cell），85卷，2025年