When we designed the Valkyrie trial several different considerations were made on how to calculate the number of patients to be recruited for the trial. In the end, the decision fell on the way as des
Breast cancer screening is effective in reducing mortality from the disease. However, the sensitivity of mammography is not optimal, which limits the effectiveness of screening, particularly in younge
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These
