SIV controllers analyzed in this study

aAnimals were unvaccinated or vaccinated with DNA-prime/SeV-boost expressing EGFP (control), Gag202–216-EGFP and Gag236–251-EGFP (Gag206–216/241–249), Gag236–251-EGFP (Gag241–249), or Gag202–216-EGFP (Gag206–216) before SIVmac239 challenge. All of them controlled SIV replication for more than 2 years.bpositive, viral gag fragments were detected by RT-PCR amplification from culture supernatant-derived RNAs of PBMCs at 2 years; negative, those were undetectable.cOn the basis of the data on proviral gag nucleotide sequences at 2 years post-infection, animals were divided into two groups, Group M with multiple mutations and Group N with no mutation.SIV controllers analyzed in this study