Genome stability of chemically induced pluripotent stem cells with or without crotonic acid. Mus musculus

Dynamics and mechanisms of telomere reprogramming of CiPSCs remain elusive. We find that histone crotonylation induced by crotonic acid can activate two-cell genes, including Zscan4; maintain telomeres; and promote CiPSC generation and pluripotency of CiPSCs. To further explore the effect on genome stability of crotonic acid addition during chemical reprogramming, we performed the whole-exome sequencing analysis.