Exploring the effect of intermolecular chirality in Diasteromeric Deep Eutectic Solvents

Chirality in deep eutectic solvents is often confined to one component, leaving the structural role of intermolecular stereochemistry unresolved. We will use ID02 to quantify how the four pairings of two homochiral components (LL, DD, LD, DL) reshape mesoscale organization. Temperature controlled flow SAXS/WAXS will deliver absolute intensities with high stability. We will extract d, ξ, q*, and low-q excess via Teubner-Strey and OZ fits and test pre-registered thresholds for ΔI/I and Δq*. A prioritized 1:1, 2:1 and 1:2 series will isolate stereochemical effects from composition. The outcome will be benchmark datasets and analysis tools that establish when diastereomeric pairing measurably changes liquid structure, providing a reference for chiral media design.