Causal mediation analysis examines the potential causal pathways between an exposure variable and outcome through intermediate variables with the goal of estimating direct and indirect effects. In pra
Childhood trauma tends to influence cortisol stress reactivity through the mediating effects of DNA methylation. Houtepen et al. conducted a study to investigate the role of DNA methylation in cortiso
High-dimensional mediation analysis has gained increasing interest in various fields, particularly in genetic and medical research. Compared with existing works that focus mainly on high-dimensional m
Mediation analysis is of rising interest in epidemiologic studies and clinical trials. Among existing methods, the joint significance test yields an overly conservative Type I error rate and low power
Causal mediation analysis examines the potential causal pathways between an exposure variable and outcome through intermediate variables with the goal of estimating direct and indirect effects. In pra
