Albumin-Energized NIR-II Cyanine Dye for Fluorescence/Photoacoustic/Photothermal Multi-Modality Imaging-Guided Tumor Homologous Targeting Photothermal Therapy

Endowing cyanine dyes with hydrophilicity, long blood
circulation,
tumor targeting, and robust therapeutic efficacy in the second near-infrared
(NIR-II) window is challenging for cancer treatment. Herein, we develop
cancer cell membrane-coated albumin-NIR-II cyanine dye assemblies,
denoted as LZ-1105@HAm, to optimize the photophysical properties of
cyanine dyes in aqueous solution for NIR-II fluorescence (FL)/photoacoustic
(PA)/photothermal (PT) multimodality imaging-guided tumor homologous
targeting photothermal therapy. LZ-1105@HAm exhibits good hydrophilicity,
extends the half-life of blood circulation from 0.634 ± 0.058
to 1.919 ± 0.107 h, enhances NIR-II FL/PA/PT imaging capabilities
in vitro and in vivo, and improves photothermal conversion efficiency
from 34.6% to 45.4%. Additionally, the cell membrane coating confers
the assemblies with tumor-specific targeting capability, increasing
tumor accumulation and enabling efficient photothermal tumor ablation.
Upon 1064 nm laser irradiation, LZ-1105@HAm demonstrates significantly
improved therapeutic efficacy. This research provides a strategy for
constructing cyanine dye-based nanotheranostics with potential clinical
application prospects.