Effectiveness of institution based rehabilitation protocol in patients with Parkinson Disease to improve Quality of Life

Background: Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease.
Purpose: To establish effectiveness of IRQoL-PD in comparison with control group treatment protocol to enhance the quality of life in patients with Parkinson’s disease.
Methods: A single centered, non equivalent pre-test post-test control group design was done with 32 participants suffering from PD with age group between 35-80 yrs who were randomly assigned into two groups. Intervention with IRQoL-PD protocol was given in experimental group for 5 weeks. In control group, patients were on medications prescribed by their respective neurologists along with home exercise. Outcome measure: UPDRS and Hoehn and Yahr scale as outcome measures.
Result: It showed that there was significant improvement in primary outcome measure i.e. UPDRS with p - value = 0.008 but secondary outcome measure i.e Hoehn and Yahr Scale didn’t show any significant difference (p-value = 0.312) between the experimental and control groups.
Conclusion: Institution based Rehabilitation protocol to improve Quality of life in patients with Parkinson’s Disease (IRQoL-PD) can be used effectively so that the patients can be benefitted globally and thus delaying the progression of disease in comparison to the conventional treatment of medications and home exercise program which proves to be insignificant when compared with the above rehabilitation protocol.

背景：帕金森病（PD）是继阿尔茨海默病之后最常见的神经退行性疾病。
目的：旨在验证基于IRQoL-PD的治疗方案相较于对照组治疗方案在提升帕金森病患者生活质量方面的有效性。
方法：采用单中心、非等价的前后测试对照组设计，纳入32名年龄介于35至80岁的帕金森病患者，随机分配至两组。实验组接受为期5周的IRQoL-PD方案干预。对照组患者继续接受各自神经科医生开具的药物并配合家庭锻炼。结果指标：使用UPDRS评分和Hoehn and Yahr量表作为结果评估指标。
结果：结果显示，实验组在主要结果指标UPDRS评分上显著改善，p值=0.008，而次要结果指标Hoehn and Yahr量表并未显示出实验组与对照组之间存在显著差异（p值=0.312）。
结论：基于机构的康复方案（IRQoL-PD）在提高帕金森病患者生活质量方面具有显著效果，能够使患者在全球范围内受益，从而延缓疾病进展，相较于传统的药物治疗和家庭锻炼方案，上述康复方案在疗效上显得更为显著。