Hematopoietic phenotype changes as a result of loss of Meis1 expression with or without NAC treatment in mouse bone marrow

Loss of Meis1 results in changes in frequency of sub populations of hematopoietic cells. This has been postulated to be, at least in part, via reactive oxygen species. We deleted Meis1 in the presence and absence of ROS scavenger N-acetylcysteine and examined the impact on hematopoietic sub-populations.
Conclusion:
NAC treatment abolishes the difference in numbers of HSC and MkP progenitors between Meis1 -/+ and Meis1 -/- mice Single stain and FMO controls