Data From RIDER_NEURO_MRI

RIDER Neuro MRI contains imaging data on 19 patients with recurrent glioblastoma who underwent repeat imaging sets. These images were obtained approximately 2 days apart (with the exception of one patient, RIDER Neuro MRI-1086100996, whose images were obtained one day apart). DCE‐MRI: All 19 patients had repeat dynamic contrast‐enhanced MRI (DCE‐MRI) datasets on the same 1.5T imaging magnet. On the basis of T2‐weighted images, technologists chose 16 image locations using 5mm thick contiguous slices for the imaging. For T1 mapping, multi‐flip 3D FLASH images were obtained using flip angles of 5, 10, 15, 20, 25 and 30 degrees, TR of 4.43 ms, TE of 2.1 ms, 2 signal averages. Dynamic images were obtained during the intravenous injection of 0.1mmol/kg of Magnevist intravenous at 3ccs/second, started 24 seconds after the scan had begun. The dynamic images were acquired using a 3D FLASH technique, using a flip angle of 25 degrees, TR of 3.8 ms, TE of 1.8 ms using a 1 x1 x 5mm voxel size. The 16 slice imaging set was obtained every 4.8 sec. DTI: Seventeen of the 19 patients also obtained repeat diffusion tensor imaging (DTI) sets. Whole brain DTI were obtained using TR 6000ms, TE 100 ms, 90 degree flip angle, 4 signal averages, matrix 128 x 128, 1.72 x 1.72 x 5 mm voxel size, 12 tensor directions, iPAT 2, b value of 1000 sec/mm2 . Contrast‐enhanced 3D FLASH: All 19 patients underwent whole brain 3D FLASH imaging in the sagittal plane after the administration of Magnevist. For this sequence, TR was 8.6 ms, TE 4.1 ms, 20 degree flip angle, 1 signal average, matrix 256 x 256; 1mm isotropic voxel size. Contrast‐enhanced 3D FLAIR: All 17 patients who had repeat DTI sets also had 3D FLAIR sequences in the sagittal plane after the administration of Magnevist. For this sequence, the TR was 6000 ms, TE 353 ms, and TI 2200ms; 180 degree flip angle, 1 signal average, matrix 256 x 216; 1 mm isotropic voxel size. Note: before transmission to NCIA, all image sets with 1mm isotropic voxel size were “defaced” using MIPAV software or manually.

RIDER 神经磁共振成像（RIDER Neuro MRI）数据集包含19例复发性胶质母细胞瘤患者的影像学数据，所有受试者均接受了重复成像扫描。上述图像的采集间隔约为2天，仅1例患者例外：RIDER Neuro MRI-1086100996，其两次成像的采集间隔仅为1天。

动态对比增强MRI（DCE-MRI）：全部19例患者均在同一台1.5T磁共振成像仪上完成了重复动态对比增强MRI（DCE-MRI）数据集。技术人员基于T2加权图像选取了16个成像层面，采用层厚5mm的连续切片完成扫描。针对T1映射成像，采用多翻转角3D FLASH序列采集图像，翻转角分别设置为5°、10°、15°、20°、25°和30°，重复时间（TR）为4.43ms，回波时间（TE）为2.1ms，信号平均次数为2次。

动态扫描于扫描开始后24秒启动，同步进行0.1mmol/kg剂量的马根维显（Magnevist）静脉注射，注射流速为3cc/秒。动态图像采用3D FLASH技术采集，翻转角为25°，TR为3.8ms，TE为1.8ms，体素大小为1×1×5mm。每4.8秒完成一次16层成像扫描。

扩散张量成像（DTI）：19例患者中有17例完成了重复扩散张量成像（DTI）扫描。全脑DTI扫描参数如下：TR 6000ms，TE 100ms，翻转角90°，信号平均次数4次，矩阵尺寸128×128，体素大小1.72×1.72×5mm，包含12个张量编码方向，iPAT 2，b值为1000 s/mm²。

对比增强3D FLASH成像：全部19例患者均在注射马根维显后完成了矢状位全脑3D FLASH成像。该序列参数为：TR 8.6ms，TE 4.1ms，翻转角20°，信号平均次数1次，矩阵尺寸256×256，体素大小为1mm各向同性。

对比增强3D FLAIR成像：完成重复DTI扫描的17例患者，均在注射马根维显后完成了矢状位3D FLAIR序列扫描。该序列参数为：TR 6000ms，TE 353ms，反转时间（TI）2200ms，翻转角180°，信号平均次数1次，矩阵尺寸256×216，体素大小为1mm各向同性。

注意事项：在传输至NCIA前，所有体素尺寸为1mm各向同性的图像数据集均使用MIPAV软件完成面部去标识化处理，或通过手动方式完成。