WP5442 - Wnt/Beta-catenin signaling inhibitors in current and past clinical trials - Homo sapiens

NIAID Data Ecosystem2026-05-02 收录

Wnt信号通路抑制剂

临床试验药物

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https://www.ndexbio.org/viewer/networks/63320858-1439-11f0-9806-005056ae3c32 数据链接链接失效反馈

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Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

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2025-04-17

DataSheet2_Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: From thienopyrimidine to quinazoline inhibitors.docx

三阴性乳腺癌药物研发

Wnt信号通路抑制剂

The Wnt-pathway has a critical role in development and tissue homeostasis and has attracted increased attention to develop anticancer drugs due to its aberrant activation in many cancers. In this stud

NIAID Data Ecosystem50

Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939

蛋白质复合物结构解析

Wnt信号通路抑制剂

Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939 Descriptor: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ... Autho

Protein Data Bank Japan2023-11-01 更新40

Crystal structure of Beta-catenin Armadillo repeats domain in complex with the inhibitor RS6452

蛋白酶-抑制剂复合物结构

Wnt信号通路抑制剂

Crystal structure of Beta-catenin Armadillo repeats domain in complex with the inhibitor RS6452 Descriptor: 4-bromanyl-~{N}-(3-pyridin-2-ylphenyl)benzenesulfonamide, Catenin beta-1 Authors: Capelli, D

Protein Data Bank Japan2024-02-07 更新40

Crystal structure of human tankyrase 2 in complex with TA-92

蛋白质晶体学

Wnt信号通路抑制剂

Crystal structure of human tankyrase 2 in complex with TA-92 Descriptor: 4-[3-(8-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2- YL)PROPANAMIDO]-N-(QUINOLIN-8-YL)BENZAMIDE, TANKYRASE-2, ZINC ION Authors: Haikar

Protein Data Bank Japan2024-05-08 更新40

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma

多发性骨髓瘤治疗

Wnt信号通路抑制剂

Dysregulation of the Wnt pathway is involved in pathogenesis of many types of carcinomas and associated with certain hematological cancers, including multiple myeloma (MM). Several studies reported th

NIAID Data Ecosystem40

WP5442 - Wnt/Beta-catenin signaling inhibitors in current and past clinical trials - Homo sapiens

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