Dataset S6. Alignment and phylogeny of primate lentiviral Vpr and Vpx proteins that were functionally tested for their capacity to degrade human HUSH – Associated to Extended Data Fig. 4e.

Vpr and Vpx amino acid sequences were retrieved from the Los Alamos HIV sequence database https://www.hiv.lanl.gov/content/sequence/NEWALIGN/align.html. The alignment was performed using PRANK and the phylogeny was done with PhyML (JTT+G+I model) with 1,000 bootstraps as node support. These data were used for Extended Data Fig. 4e.Files:DatasetS6-aln0.fas : Fasta alignmentDatasetS6-aln1.pdf : PDF preview of the alignmentDatasetS6_tree0.txt : Phylogeny in Newick formatDatasetS6_tree1.pdf: Phylogeny in a pdf format with color-coding (corresponding to Extended Data Fig 4e).