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Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires

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NIAID Data Ecosystem2026-05-02 收录
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Identification of potent antibodies in human serum is difficult due to limited B cells targeting specific antigens. Our efficient method enriches high-affinity antibodies against pathogens, even without knowledge on immunogens structure. Our two-step screening approach allows the selection selects high-affinity therapeutic human antibodies, in particular against SARS-CoV-2 spike protein, within weeks.

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2024-05-27
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