Dissecting the Overlaps. Evaluation of the Relationships Between Neurological Soft Signs, Schizotypy and Interoceptive Awareness in Obsessive Compulsive Disorder.

Obsessive Compulsive Disorder's (OCD) etiology remains unknown. Identifying the relationships between neurological noft signs (NSSs), schizotypy, and interoceptive awareness may be helpful to clarify the neurodevelopment of OCD. In this cross-sectional study; relations between neurological soft signs, schizotypal traits and interoceptive awareness was evaluated. Between April 2023 and August 2023, thirty participants who applied to the Psychiatry Outpatient and Inpatient Clinics of Gazi University, Department of Psychiatry and diagnosed as obsessive compulsive disorder were included in this study. Thirty healthy subjects without any psychiatric or neurological diseases were included in as the control group. All the participants were required to fill out sociodemographic information form, Schizotypal Personality Questionnaire (SPQ), Multidimensional Assessment of Interoceptive Awareness-2 (MAIA-2), Hospital Anxiety and Depression Scale (HADS) and Yale Brown Obsessive Compulsive Scale (Y-BOCS). All subjects were examined for neurological soft signs by using the Neurological Evaluation Scale (NES). There was no significant difference between the groups in terms of age, gender, hand, foot, and eye preferences, and cerebral dominance. In the patient group analysis, there was a negative correlation between MAIA-2-Not Distracting subscale and NES-Sensorimotor Integration and NES-Other subscales; MAIA-2-Noticing subscale and SPQ-Interpersonal Schizotypy and SPQ-Disorganized Schizotypy sub-dimensions; MAIA-2-Trusting subscale and all SPQ sub-dimensions. It was thought that the study results could contribute to the understanding of the neurodevelopmental aspects of OCD.强迫症（Obsessive Compulsive Disorder, OCD）的病因迄今尚未明确。明确神经软体征（Neurological Soft Signs, NSSs）、分裂型特质与内感受觉知之间的关联，或有助于阐明强迫症的神经发育机制。本项横断面研究对神经软体征、分裂型特质与内感受觉知之间的关联进行了评估。2023年4月至2023年8月期间，本研究纳入了在加齐大学精神病学系精神科门诊及住院诊所就诊、并被确诊为强迫症的30名受试者；另纳入30名无任何精神或神经系统疾病的健康受试者作为对照组。所有受试者均需填写社会人口学问卷、分裂型人格问卷（Schizotypal Personality Questionnaire, SPQ）、内感受觉知多维评估量表-2（Multidimensional Assessment of Interoceptive Awareness-2, MAIA-2）、医院焦虑抑郁量表（Hospital Anxiety and Depression Scale, HADS）以及耶鲁-布朗强迫症量表（Yale Brown Obsessive Compulsive Scale, Y-BOCS）。所有受试者均采用神经评估量表（Neurological Evaluation Scale, NES）进行神经软体征检查。两组受试者在年龄、性别、利手、利足、利眼及大脑偏侧性方面均无显著差异。患者组分析结果显示，MAIA-2的「不受干扰」子量表与NES的感觉运动整合子量表、NES其他子量表呈负相关；MAIA-2的「觉察觉知」子量表与SPQ的人际分裂型特质、瓦解型分裂型特质子维度呈负相关；MAIA-2的「信任」子量表与SPQ所有子维度均呈负相关。本研究结果或有助于加深对强迫症神经发育层面的认识。