Navigated ultrasound bronchoscopy with integrated positron emission tomography - A human feasibility study

Patients suspected to have lung cancer undergo endobronchial ultrasound bronchoscopy (EBUS) for the purpose of diagnosis and staging. For presumptive curable patients, the EBUS bronchoscopy is planned based on images and data from computed tomography (CT) images and positron emission tomography (PET). Our study aimed to evaluate the feasibility of a multimodal electromagnetic (EM) navigation platform for EBUS bronchoscopy, integrating ultrasound and segmented CT, and PET scan imaging data. This proof-of-concept study included patients with suspected lung cancer identified on both CT and PET scans. Images obtained from these two modalities were segmented to delineate target lymph nodes and then incorporated into the CustusX navigation platform. The EBUS bronchoscope was equipped with a 3D printed click-on device with an integrated EM sensor at the tip. Navigation accuracy was measured postoperatively using ultrasound recordings. The study enrolled three patients, all presenting with susp..., , , # Navigated ultrasound bronchoscopy with integrated positron emission tomography - A human feasibility study [https://doi.org/10.5061/dryad.6t1g1jx78](https://doi.org/10.5061/dryad.6t1g1jx78) ## Description of the data and file structure The dataset contains thorax computed tomography (CT), positron emission tomography (PET), and ultrasound data from 3 patients undergoing endobronchial ultrasound bronchoscopy (EBUS) with transbronchial needle aspirations (TBNA). The PET data is registered (non-linear) to the CT data. Ultrasound data is aligned to the corresponding position of CT data using electromagnetic tracking (EMT). ### Files and variables CT: Thorax computed tomography (CT), .mhd/.raw format PET: Positron emission tomography (PET) registered to CT, .mhd/.raw format Ultrasound: Ultrasound data of lymph nodes, .mhd/.zraw format (.mhd files can be transferred to another format (i.e., .nii) in Python using ReadImage/WriteImage in SimpleITK)疑似肺癌患者接受支气管内超声支气管镜检查（endobronchial ultrasound bronchoscopy, EBUS）以完成诊断与临床分期。对于拟接受根治性治疗的患者，EBUS检查方案基于计算机断层扫描（computed tomography, CT）与正电子发射断层扫描（positron emission tomography, PET）获取的影像及数据制定。本研究旨在评估一款集成超声、分割后CT及PET扫描影像数据的多模态电磁（electromagnetic, EM）导航平台应用于EBUS检查的可行性。本概念验证研究纳入了经CT与PET扫描检出的疑似肺癌患者。对两种模态获取的影像进行分割以勾勒靶区淋巴结，随后将其整合至CustusX导航平台中。EBUS支气管镜配备了一款3D打印的卡扣式装置，其顶端集成了EM传感器。术后通过超声录像评估导航精度。本研究共纳入3例患者，均表现为疑似[原文截断]……# 集成正电子发射断层扫描的导航超声支气管镜检查——一项人体可行性研究 [https://doi.org/10.5061/dryad.6t1g1jx78](https://doi.org/10.5061/dryad.6t1g1jx78) ## 数据集与文件结构说明 本数据集包含3例接受EBUS联合经支气管针吸活检（transbronchial needle aspirations, TBNA）的患者的胸部计算机断层扫描（CT）、正电子发射断层扫描（PET）及超声影像数据。 PET数据已通过非线性配准方式与CT数据完成配准。 超声数据通过电磁跟踪（electromagnetic tracking, EMT）匹配至CT数据的对应解剖位置。 ### 文件与变量 CT：胸部计算机断层扫描（CT）数据，格式为.mhd/.raw PET：与CT配准后的正电子发射断层扫描（PET）数据，格式为.mhd/.raw 超声：淋巴结超声影像数据，格式为.mhd/.zraw （可通过Python中SimpleITK库的ReadImage与WriteImage函数，将.mhd格式文件转换为.nii等其他格式）