Identification and prevalence of adverse drug events caused by potentially inappropriate medication in homebound elderly patients: a retrospective study using a nationwide survey in Japan

Objectives: A nationwide large-scale survey was conducted to identify the prevalence and causal medications of adverse drug events (ADEs) that are caused by potentially inappropriate medications (PIMs) given to homebound elderly patients, factors associated with ADEs, and measures taken by pharmacists to manage ADEs and their effects on ADEs. Settings: A questionnaire was mailed to 3321 pharmacies nationwide. It asked about the details of PIMs and ADEs of up to 5 patients for whom home visits were provided by a pharmacist. Questionnaire forms were filled in by pharmacists who visited the patients. Design and participants: Between 23 January and 13 February 2013, comprehensive assessment forms were sent to 3321 pharmacies. Data collected from 1890 pharmacies including data of 4815 patients were analysed and 28 patients of unknown sex were excluded. Their average age was 82.7 years. PIMs were identified based on the 2003 Beers Criteria Japan. Results: There were 600 patients who did not p...研究目的：本研究开展一项全国性大规模调查，旨在明确居家老年患者使用潜在不适当药物（potentially inappropriate medications, PIMs）引发的药物不良事件（adverse drug events, ADEs）的患病率与致病药物种类，分析与药物不良事件相关的影响因素，并探究药师针对药物不良事件采取的干预措施及其对事件的改善效果。 研究场景：本研究向全国3321家药房邮寄调查问卷，要求填写药师上门巡诊的至多5名患者的潜在不适当药物与药物不良事件详情，问卷由为患者提供上门服务的药师完成填写。 研究设计与研究对象：2013年1月23日至2月13日期间，研究人员向3321家药房发放全面评估问卷。最终对1890家药房提交的数据进行分析，该部分数据涉及4815名患者，排除28例性别信息不明的患者，纳入分析的患者平均年龄为82.7岁。潜在不适当药物的判定依据2003年版日本Beers标准（2003 Beers Criteria Japan）。 研究结果：共计600名患者未发生……