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A genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM

NIAID Data Ecosystem2026-03-11 收录

胶质母细胞瘤耐药性

EGFRvIII突变机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112736 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-06-04

胶质母细胞瘤耐药性

RNA表达谱

Glioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after surgery can prolong survival,

NIAID Data Ecosystem110

Activation of STAT3 through SRC and EGFR Drives Resistance to a Mitotic Kinesin Inhibitor in Glioblastoma

胶质母细胞瘤耐药性

靶向治疗信号通路

The outcome for patients afflicted with glioblastoma (GBM), the most common and malignant of primary brain tumors in adults, has changed little despite decades of clinical, translational, and basic re

NIAID Data Ecosystem70

Additional file 10 of Drug resistant glioblastoma stem cells exhibit enriched stemness signatures and share extracellular matrix overexpression

胶质母细胞瘤耐药性

肿瘤干细胞差异表达基因

Additional file 10. Differentially expressed genes. Complete list of the differentially expressed genes between the drug-resistant and drug-sensitive GSC cultures.

Figshare2025-10-27 更新50

Glioblastoma stem cell (GSC) clones survived 500uM Temozolomide (TMZ) treatment. Homo sapiens

胶质母细胞瘤耐药性

癌细胞基因表达

Comparison of parental GSC (GSC-parental) with treatment resistant GSC clones survived 500uM TMZ treatment (GSC-500uM TMZ) We used microarrays to identify defense profiles of GSC-500uM TMZ Overall des

NIAID Data Ecosystem80

Rational targeting of dynamic tumor subclones in relapsing human glioblastoma

胶质母细胞瘤耐药性

肿瘤亚克隆动态分析

Glioblastoma therapy relies on the alkylating drug temozolomide (TMZ) administered to irradiated patients post-neurosurgery, which increases overall survival but cannot prevent fatal disease relapse.

NIAID Data Ecosystem50

A genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM

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