Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Descriptor: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Serine/threonine-protein kinase receptor R3 Authors: Chaikuad, A, Alfano, I, Cooper, C, Mahajan, P, Daga, N, Sanvitale, C, Fedorov, O, Petrie, K, Savitsky, P, Gileadi, O, Sethi, R, Krojer, T, Muniz, J.R.C, Pike, A.C.W, Vollmar, M, Carpenter, C.P, Ugochukwu, E, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) Deposit date: 2010-05-08 Release date: 2010-07-21 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis, 18, 2015

与LDN-193189结合的ACVRL1（ALK1）激酶域晶体结构
描述：4-[6-(4-哌嗪-1-基苯基)吡唑并[1,5-a]嘧啶-3-基]喹啉，丝氨酸/苏氨酸蛋白激酶受体R3
作者：Chaikuad, A, Alfano, I, Cooper, C, Mahajan, P, Daga, N, Sanvitale, C, Fedorov, O, Petrie, K, Savitsky, P, Gileadi, O, Sethi, R, Krojer, T, Muniz, J.R.C, Pike, A.C.W, Vollmar, M, Carpenter, C.P, Ugochukwu, E, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, 结构基因组学联盟（Structural Genomics Consortium, SGC）
提交日期：2010-05-08
发布日期：2010-07-21
最后修改日期：2023-11-01
实验方法：X射线衍射（分辨率2.65埃）
引用文献：靶向ALK1的小分子可阻断Notch协同作用并抑制功能性血管生成。《血管生成》，18卷，2015年