Expression data from hyperoxaluric rats

Calcium oxalate stones account for over 80% of urinary stones, while the molecular mechanism of its formation is still not completely elucidated. The incidence of hyperoxaluria in calcium oxalate stone formation ranks only second to hypercalciuria. It plays an important role in the pathophysiological process of stone formation. We analyzed miRNA expression profiles between experimental hyperoxaluric rats and normal rats in order to find out the target genes and signaling pathways in the pathogenesis of hyperoxaluria.草酸钙结石（Calcium oxalate stones）占尿路结石的80%以上，但其形成的分子机制仍未完全阐明。在草酸钙结石形成过程中，高草酸尿症（hyperoxaluria）的发病率仅次于高钙尿症（hypercalciuria）。高草酸尿症在结石形成的病理生理过程中发挥重要作用。本研究通过分析实验性高草酸尿症大鼠与正常大鼠的miRNA（microRNA）表达谱，以期探寻高草酸尿症发病机制中的靶基因与信号通路。