Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
收藏reactome.org2025-03-23 收录
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Cdh1:APC/C complex, stabilized by the DNA damage-induced ATM-TP53-CDKN1A axis, ubiquitinates EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases, targeting them for degradation (Takahashi et al. 2012).
Cdh1:APC/C 复合体,由DNA损伤诱导的ATM-TP53-CDKN1A 轴稳定,泛素化EHMT1(GLP)和EHMT2(G9a)组蛋白甲基转移酶,将其靶向降解(Takahashi等,2012年)。
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