Ensembl

The Ensembl project produces genome databases for vertebrates and other eukaryotic species. Ensembl is a joint project between the European Bioinformatics Institute (EBI) and the Wellcome Trust Sanger Institute (WTSI) to develop a software system that produces and maintains automatic annotation on selected genomes.The Ensembl project was started in 1999, some years before the draft human genome was completed. Even at that early stage it was clear that manual annotation of 3 billion base pairs of sequence would not be able to offer researchers timely access to the latest data. The goal of Ensembl was therefore to automatically annotate the genome, integrate this annotation with other available biological data and make all this publicly available via the web. Since the website's launch in July 2000, many more genomes have been added to Ensembl and the range of available data has also expanded to include comparative genomics, variation and regulatory data. Ensembl is a joint project between European Bioinformatics Institute (EBI), an outstation of the European Molecular Biology Laboratory (EMBL), and the Wellcome Trust Sanger Institute (WTSI). Both institutes are located on the Wellcome Trust Genome Campus in Hinxton, south of the city of Cambridge, United Kingdom.

Ensembl项目致力于为脊椎动物及其他真核生物物种构建基因组数据库。Ensembl项目由欧洲生物信息学研究所（EBI）与威康信托桑格研究所（WTSI）共同发起，旨在开发一套软件系统，以自动对选定的基因组进行注释并维护。该项目始于1999年，早于人类基因组草图完成数年。即便在早期阶段，显而易见的是，对30亿碱基对的序列进行手动注释无法为研究人员提供及时获取最新数据的途径。因此，Ensembl项目的目标是自动注释基因组，将此注释与其他可用的生物数据整合，并通过网络向公众提供所有这些信息。自2000年7月网站启动以来，Ensembl已添加了更多的基因组，并扩展了可用数据的范围，包括比较基因组学、变异和调控数据。Ensembl项目由欧洲生物信息学研究所（European Bioinformatics Institute, EBI），欧洲分子生物学实验室（European Molecular Biology Laboratory, EMBL）的分支机构，与威康信托桑格研究所（Wellcome Trust Sanger Institute, WTSI）共同承担。这两个研究所均位于英国剑桥市南部的威康信托基因组园区。