Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=1a5c640475d7d0456ec089eb6170e0ad
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资源简介：
GABAergic interneurons (GINs) are a heterogeneous class of inhibitory neurons that collectively maintain normal neuronal excitability and network activity. Identification of the genetic regulatory elements and transcription factors that contribute toward GIN function may provide new insight into the pathways underlying proper GIN activity, while also indicating potential therapeutic targets for GIN-associated disorders, such as epilepsy and schizophrenia. In this study, we examined temporal changes in gene expression and chromatin accessibility by collecting human iPSC-derived GINs at three time points for transcriptomic and epigenomic analysis: neural progenitor cells at 22 days post-differentiation (D22), then GINs at D50 and D78. Collectively, these data provide a resource for examining the molecular networks regulating normal GIN functionality.
提供机构：
Emory University
创建时间：
2022-02-20
