Data underlying the publication: Enhancing trigger sensitivity of nanocarriers through organocatalytic oxidant activation

This dataset contains data underlying the publication: “Enhancing trigger sensitivity of nanocarriers through organocatalytic oxidant activation"collected as part of Irene Piergentili's PhD Thesis project. It is being made public to act as supplementary data for the publication and additionally for the PhD thesis of Irene Piergentili. These data were made available for other researchers to use in their own work. The data in this data set was collected in the Department of Chemical Engineering and Department of Radiation Science and Technology of the Delft University of Technology - Faculty of Applied Science, between March 2021 and January 2023. This research project was made possible by a grant from the Netherlands Organisation for Scientific Research and the National Natural Science Foundation of China (NWO-NSFC joint project). The purpose of these experiments was to investigate the use of organocatalysis on thioanisole ester based micelles as oxidation-sensitive drug delivery and release carrier. Thioanisole ester based micelles in presence of organocatalysis were investigated via several techniques: Nuclear Magnetic Resonance (NMR), Dynamic Light Scattering (DLS)and Fluorescence Spectroscopy. The data were collected manually using the timestamp of the obtained file as time point in the kinetic experiments. NMR data are provided as raw unprocessed .fid data files as well as log text files containing time of measurement information. DLS data are provided as an .xlsx output from Malvern Zetasizer including information around scatter count, Z-average diameter, Intensity and Number plots, Number average size. Fluorescence Spectroscopy was used to quantify the Nile Red release from the micelles and raw data are provided as .jws files.<br>

本数据集支撑发表论文《通过有机催化氧化活化提升纳米载体的触发敏感性》（Enhancing trigger sensitivity of nanocarriers through organocatalytic oxidant activation）的相关研究，其采集自Irene Piergentili的博士学位论文课题。本数据集作为该论文的补充数据公开，同时可供Irene Piergentili的博士学位论文使用，并开放给其他研究人员用于其自身研究工作。
本数据集的采集工作于2021年3月至2023年1月期间，在代尔夫特理工大学（Delft University of Technology）应用科学学院化学工程系与辐射科学与技术系完成。
本研究项目得益于荷兰科学研究组织（Netherlands Organisation for Scientific Research）与中国国家自然科学基金委员会（National Natural Science Foundation of China，NSFC）的联合项目（NWO-NSFC联合项目）资助。
本次实验的目的为探究有机催化在基于茴香硫醚酯的胶束作为氧化敏感性药物递送与释放载体中的应用。
研究通过多种技术对有机催化环境下的茴香硫醚酯胶束进行表征，包括核磁共振（Nuclear Magnetic Resonance, NMR）、动态光散射（Dynamic Light Scattering, DLS）以及荧光光谱法。
本次实验数据以所得文件的时间戳作为动力学实验的时间节点，通过手动方式采集。
核磁共振数据以未处理的原始.fid数据文件，以及包含测量时间信息的日志文本文件形式提供。
动态光散射数据以马尔文粒度仪（Malvern Zetasizer）导出的.xlsx格式文件提供，其中包含散射计数、Z平均粒径、强度与数量分布图、数均粒径等信息。
荧光光谱法用于定量分析胶束中尼罗红的释放过程，原始数据以.jws文件格式提供。