Dataset for Systematic Review and Meta-Analysis: Angiotensin-(1-7) as a Therapeutic Agent for Skeletal Muscle Disorders

This dataset contains quantitative data extracted from studies included in the systematic review and meta-analysis entitled "Angiotensin-(1-7) as a therapeutic agent for skeletal muscle disorders: a systematic review and meta-analysis." Data were obtained from published experimental studies evaluating the effects of Angiotensin-(1-7) [Ang-(1-7)] on skeletal muscle in in vitro, animal, and human models.
Research Hypothesis
The central hypothesis is that Angiotensin-(1-7) [Ang-(1-7)] acts as a potent therapeutic agent for skeletal muscle disorders by counteracting muscle wasting and dysfunction through the Mas receptor. It is proposed that this peptide shifts the muscle's metabolic balance from a catabolic state (atrophy and degradation) to an anabolic state (regeneration and protein synthesis).
The dataset is organized in a single spreadsheet tab, with each row representing one measurement from a specific experimental condition and group. Data are separated by study (Experiment ID) and experimental group, and include the following variables: muscle fiber size distribution (percentage of small fibers as an indicator of atrophy), quantitative markers of protein synthesis and degradation (including MHC, myogenin, alpha-actinin, MuRF-1, and Atrogin-1), functional outcomes (isometric and tetanic force, grip strength, and treadmill performance), muscle mass measurements, and inflammatory markers (TNF-α). Each entry reports the mean value, standard error or standard deviation, the experimental condition and treatment group, the biological model, and the source figure from the original publication.
Studies included models of skeletal muscle atrophy induced by denervation, disuse/immobilization, myostatin, angiotensin II, endotoxin (LPS), transforming growth factor-beta (TGF-β), eccentric exercise, chronic liver disease, aging, and Duchenne muscular dystrophy. Human data were also included where available.
No formatting, formulas, or calculations were added to the raw data file, in compliance with open data repository standards.