Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC Analog, (E)-3-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)acrylic acid

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC Analog, (E)-3-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)acrylic acid Descriptor: 3-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}prop-2-enoic acid, Estrogen receptor, Nuclear receptor coactivator 2 Authors: Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-12 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

与OBHS-ASC类似物[(E)-3-(4-((1R,4S,6R)-6-((3-氯苯氧基)磺酰基)-3-(4-羟苯基)-7-氧杂双环[2.2.1]庚-2-烯-2-基)苯基)丙烯酸]结合的雌激素受体α（ER-alpha）配体结合结构域（Y537S突变体）的晶体结构
描述物：3-{4-[(1S,4S,6R)-6-[(3-氯苯氧基)磺酰基]-3-(4-羟苯基)-7-氧杂双环[2.2.1]庚-2-烯-2-基]苯基}丙-2-烯酸
研究对象：雌激素受体、核受体辅激活因子2
作者：Nwachukwu J.C、Srinivasan S、Bruno N.E、Nowak J、Kojetin D.J、Elemento O、Katzenellenbogen J.A、Nettles K.W
沉积日期：2016-10-12
发布日期：2017-01-18
最后修改日期：2024-03-06
实验方法：X射线衍射（分辨率2.5 Å）
引用文献：《配体对ER-α的影响的系统结构生物学分析可预测环境雌激素与抗激素治疗的细胞应答》，发表于Cell Chem Biol，第24卷，2017年